the relationship between coronary artery disease and genetic polymorphisms of melanoma inhibitory activity 3
نویسندگان
چکیده
materials and methods genotyping of the mia3 gene was undertaken using taqman real-time pcr in all subjects. anthropometric and biochemical features, including hdl, ldl, and tg were assessed in all subjects. results the cad patients had significantly (p < 0.05) higher bmi and significantly higher levels of tg, ldl, sbp, and dbp, while the level of hdl was lower compared to that of the control group. the mia3 gene polymorphism was not associated with cad in our population sample. background melanoma inhibitory activity 3 regulates the plasma level of ldl cholesterol. the c.3169 + 315g > a single-nucleotide polymorphism of the mia3 gene has been reported to be associated with serum coronary artery disease (cad). however, there have been no studies analyzing the association of this polymorphism with cad in iranian individuals with cad. conclusions the mia3 polymorphism is unlikely to play an important role in cad in the iranian population. however, further studies are needed in a larger population to confirm this. objectives therefore, in the present study we have investigated the potential protective effect of the rs3008621 mia3 polymorphism in 188 subjects with and without cad.
منابع مشابه
The Relationship Between Coronary Artery Disease and Genetic Polymorphisms of Melanoma Inhibitory Activity 3
BACKGROUND Melanoma Inhibitory Activity 3 regulates the plasma level of LDL cholesterol. The c.3169 + 315G > A single-nucleotide polymorphism of the MIA3 gene has been reported to be associated with serum coronary artery disease (CAD). However, there have been no studies analyzing the association of this polymorphism with CAD in Iranian individuals with CAD. OBJECTIVES Therefore, in the prese...
متن کاملGenetic Polymorphisms of Estrogen Receptors in Iranian Women with Diabetes and Coronary Artery Disease
Estrogen might play an important role in the pathogenesis of diabetes mellitus type 2. Estrogens inhibit diabetes via distinct mechanisms particularly by reducing both hyperglycemia and plasma insulin levels. Estrogen exerts its physiological effects mainly through estrogen receptors including α and β types. Estrogen receptors are found in many tissues that participate in the pathogenesis of ty...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
THE RELATIONSHIP BETWEEN OXIDATIVE STRESS AND THE ONSET OF CORONARY ARTERY DISEASE
Oxidation of low density lipoprotein (LDL) particles plays a key role in the etiology of atherosclerosis and coronary artery disease (CAD). Oxidative stress enhances the likelihood of LDL oxidation and atherosclerotic plaque development. Paraoxonase (PONI) is an enzyme associated with HDL that metabolizes organophosphates and has antioxidant activity. In order to investigate the relationsh...
متن کاملthe relationship between learners critical thinking ability and their performance in the reading sections of the tofel and ielts test
the study reflected in this thesis aims at finding out relationships between critical thinking (ct), and the reading sections of tofel and ielts tests. the study tries to find any relationships between the ct ability of students and their performance on reading tests of tofel and academic ielts. however, no research has ever been conducted to investigate the relationship between ct and the read...
15 صفحه اولمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian red crescent medical journalجلد ۱۸، شماره ۹، صفحات ۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023